XPC Polyclonal Antibody (E-AB-53352)
For research use only.
| Verified Samples |
Verified Samples in IHC: Human brain |
| Dilution | IHC 1:30-1:150 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human XPC |
| Abbre | XPC |
| Synonyms | DNA repair protein complementing XP C cells, DNA repair protein complementing XP-C cells, DNA repair protein complementing XPC cells , RAD4, Xeroderma pigme, Xeroderma pigmentosum complementation group C, Xeroderma pigmentosum group C complementing protein, p125 |
| Swissprot | |
| Cellular Localization | Nucleus. Cytoplasm. Omnipresent in the nucleus and consistently associates with and dissociates from DNA in the absence of DNA damage. Continuously shuttles between the cytoplasm and the nucleus, which is impeded by the presence of NER lesions. |
| Concentration | 0.66 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Antigen affinity purification |
| Research Areas | Epigenetics and Nuclear Signaling |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | The protein encoded by this gene is a key component of the XPC complex, which plays an important role in the early steps of global genome nucleotide excision repair (NER). The encoded protein is important for damage sensing and DNA binding, and shows a preference for single-stranded DNA. Mutations in this gene or some other NER components can result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene. |
Other Clones
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Other Formats
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Unconjugated
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