WRN Polyclonal Antibody (E-AB-53558)
For research use only.
| Verified Samples |
Verified Samples in IHC: Human gastric cancer, Human breast cancer |
| Dilution | IHC 1:30-1:150 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human WRN |
| Abbre | WRN |
| Synonyms | RecQ like type 3, DKFZp686C2056, DNA helicase, Exonuclease WRN, HGNC 12791, OTTHUMP00000225301, RECQL2, RECQL3, RecQ protein-like 2, RecQ-like type 3, RecQ3, Werner, Werner syndrome ATP-dependent helicase, Werner syndrome helicase, Werner syndrome protein |
| Swissprot | |
| Cellular Localization | Nucleus>nucleolus. Nucleus. |
| Concentration | 0.8 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Antigen affinity purification |
| Research Areas | Cancer, Epigenetics and Nuclear Signaling |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging. |
Other Clones
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Other Formats
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Unconjugated
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