Uncoated Mouse PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) ELISA Kit (E-UNEL-M0137)
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For research use only.
Product Summary
The new series of Elabscience® Uncoated ELISA kits contain the basic components required for the ELISA experiments. For customers who have rich experience and can establish their own ELISA system, uncoated kit is an ideal choice to save costs.
| Detection Range | 62.5-4000 pg/mL |
| Sample Volume | 100 μL |
| Total Assay Time | 24 h |
| Reacitivity | Mouse |
| Specificity | This kit recognizes Mouse PCSK9 in samples.No significant cross-reactivity or interference between Mouse PCSK9 and analogues was observed |
| Recovery | 80%-120% |
| Sample Type | Serum, plasma |
| Detection Method | Colorimetric method, ELISA, Sandwich |
| Assay Type | Sandwich-ELISA |
| Size | 96T*5 / 96T*15 |
| Storage | -20℃ |
| Expiration Date | 12 months |
Background
Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR); very low density lipoprotein receptor (VLDLR); apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2); and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation. Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner. Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway. Inhibits epithelial Na+ channel (ENaC)-mediated Na+ absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation. Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways.
| Uniport ID | Q80W65 |
| Research Area | Cancer, Cell Biology, Cardiovascular, Metabolism, Signal Transduction, Stem Cells |
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