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For research use only.

Verified Samples Verified Samples in IHC: Human ovarian cancer, Human brain
Dilution IHC 1:100-1:300
Isotype IgG
Host Rabbit
Reactivity Human
Applications IHC
Clonality Polyclonal
Immunogen Recombinant protein of human TONSL
Abbre TONSL
Synonyms I kappa B related protein,  I-kappa-B-related protein,  IKBR,  IkappaBR,  Inhibitor of kappa B related protein,  Inhibitor of kappa B-related protein,  MMS22L-interacting protein,  NF kappa B inhibitor like protein 2,  NF-kappa-B i,  NFBIL2/TONSL
Swissprot
Cellular Localization Cytoplasm. Nucleus. Mainly nuclear. Localizes to DNA damage sites, accumulates at stressed replication forks.
Concentration 0.6 mg/mL
Buffer Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Purification Method Affinity purification
Research Areas Cancer,  Epigenetics and Nuclear Signaling,  Signal Transduction
Conjugation Unconjugated
Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
background The protein encoded by this gene is thought to be a negative regulator of NF-kappa-B mediated transcription.The encoded protein may bind NF-kappa-B complexes and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA.Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus.
Other Clones

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Unconjugated

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