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200μL $ 399.00
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For research use only.

Verified Samples Verified Samples in WB: Jurkat, Mouse liver, HepG2, NIH/3T3
Verified Samples in IF: Mouse kidney
Dilution WB 1:500-1:2000,  IHC 1:100-1:300
Isotype IgG
Host Rabbit
Reactivity Human,  Mouse,  Rat
Applications WB,  IHC-p
Clonality Polyclonal
Immunogen Synthesized peptide derived from the Internal region of human TGFβ RII
Abbre TGF β Receptor II
Synonyms AAT3,  FAA3,  LDS1B,  LDS2,  LDS2B,  MFS2,  RIIC,  TAAD2,  TGF beta receptor type 2,  TGF beta receptor type II,  TGF beta receptor type IIB,  TGF beta type II receptor,  TGF-beta receptor type II,  TGF-beta receptor type-2,  TGF-beta type II receptor,  TGF-beta-R2,  TbetaR II,  TbetaR-II
Swissprot
Calculated MW 65 kDa
Observed MW 65 kDa

Western blotting is a method for detecting a certain protein in a complex sample based on the specific binding of antigen and antibody. Different proteins can be divided into bands based on different mobility rates. The mobility is affected by many factors, which may cause the observed band size to be inconsistent with the expected size. The common factors include:

1. Post-translational modifications: For example, modifications such as glycosylation, phosphorylation, methylation, and acetylation will increase the molecular weight of the protein.

2. Splicing variants: Different expression patterns of various mRNA splicing bodies may produce proteins of different sizes.

3. Post-translational cleavage: Many proteins are first synthesized into precursor proteins and then cleaved to form active forms, such as COL1A1.

4. Relative charge: the composition of amino acids (the proportion of charged amino acids and uncharged amino acids).

5. Formation of multimers: For example, in protein dimer, strong interactions between proteins can cause the bands to be larger. However, the use of reducing conditions can usually avoid the formation of multimers.

If a protein in a sample has different modified forms at the same time, multiple bands may be detected on the membrane.

Cellular Localization Cytoplasm
Concentration 1 mg/mL
Buffer Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol.
Purification Method Affinity purification
Research Areas Cancer,  Signal Transduction,  Stem Cells
Conjugation Unconjugated
Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
background TGFBR2 (Transforming Growth Factor Beta Receptor 2) is a Protein Coding gene.Diseases associated with TGFBR2 include Loeys-Dietz Syndrome 2 and Esophageal Cancer.Among its related pathways are SMAD2/3 MH2 Domain Mutants in Cancer and Extracellular vesicle-mediated signaling in recipient cells.GO annotations related to this gene includetransferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity.An important paralog of this gene is ACVR2B.
Other Clones

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Unconjugated

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