SEPT4 Polyclonal Antibody (E-AB-16226)
For research use only.
| Verified Samples |
Verified Samples in IHC: Human liver cancer, Human thyroid cancer |
| Dilution | IHC 1:50-1:200 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human SEPT4 |
| Abbre | SEPT4 |
| Synonyms | ARTS, Apoptosis-related protein in the TGF-beta signaling pathway, Bradeion, Bradeion beta, Brain protein H5, CE5B3, CE5B3 beta, Cell division control-related protein 2, Cerebral protein 7, H5, MART, PNUTL2, Peanut-like protein 2, SE, SEP 4, SEP4, Sept4, hCDCREL-2, hucep-7 |
| Swissprot | |
| Cellular Localization | Cytoplasm. Cytoplasm>cytoskeleton. In platelets, found in areas surrounding alpha-granules and Mitochondrion. Nucleus. While predominantly localized in the mitochondria under resting conditions, isoform ARTS translocates into the nucleus after TGF-beta treatment and apoptosis induction. |
| Concentration | 0.5 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cell Biology, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is highly expressed in brain and heart. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. One of the isoforms (known as ARTS) is distinct; it is localized to the mitochondria, and has a role in apoptosis and cancer. |
Other Clones
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Other Formats
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Unconjugated
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