SAV1 Polyclonal Antibody (E-AB-19264)
For research use only.
| Verified Samples |
Verified Samples in IHC: Human brain, Human gastric cancer |
| Dilution | IHC 1:100-1:300 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Fusion protein of human SAV1 |
| Abbre | SAV1 |
| Synonyms | Drosophila, homolog of, 1700040G09Rik, 45 kDa WW domain protein, Protein salvador homolog 1, SAV, SAV 1, SAV1, Salvador, Salvador homolog 1, WW 45, WW domain containin, hWW 45, hWW45, salvador family WW domain containing protein 1, salvador homolog 1 (Drosophila) |
| Swissprot | |
| Cellular Localization | Nucleus. Cytoplasm. |
| Concentration | 1.32 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Antigen affinity purification |
| Research Areas | Signal transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor. |
Other Clones
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Other Formats
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Unconjugated
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