SAE1 Monoclonal Antibody (AN200081P)

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	100μL	$ 320.00

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Verified Samples	Verified Samples in IF: Hela
Dilution	ICC/IF 1:20-1:100,
Isotype	IgG2b
Host	Mouse
Reactivity	Human
Applications	ICC/IF
Clonality	Monoclonal
Immunogen	Recombinant Human SAE1 protein
Abbre	SAE1
Synonyms	AOS, SUA, SAE, AOS1, SUA1, UBLE1A, SAE1, Activator of SUMO1, HSPC140, Sentrin/SUMO activating protein AOS1, SUMO 1 activating enzyme E1 N subunit, SUMO 1 activating enzyme subunit 1, SUMO-activating enzyme subunit 1, Ubiquitin like protein SUMO1 activating enzyme, Ubiquitin-like 1-activating enzyme E1A, UBL E1A
Swissprot	Q9UBE0
Concentration	1 mg/mL
Buffer	0.2 μm filtered solution in PBS
Purification Method	Protein A
Research Areas	Cell Biology
Clone No.	2D8
Conjugation	Unconjugated
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
Shipping	Ice bag
background	SAE1 belongs to the ubiquitin-activating E1 family. It is a heterodimer that acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It functions as a UBLI E1 ligase mediating the ATP-dependent activation of UBL1. SAE1 binds with UBLE1A and UBLE1B to form a heterodimer which can bind UBL1. SAE1 also regulates ATP-dependent activation of SUMO proteins and formation of a thioester with a conserved cysteine residue on SAE2. SAE1 and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins.

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Unconjugated