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For research use only.

Verified Samples Verified Samples in IHC: Human kidney
Dilution IHC-P 1:50-1:200,  
Isotype IgG
Host Rabbit
Reactivity Human
Applications IHC-P
Clonality Rabbit Monoclonal
Immunogen Recombinant Human XPNPEP2 protein
Abbre XPNPEP2
Synonyms X-Pro Aminopeptidase,  Xaa-Pro Aminopeptidase,  Xpnpep,  Aminoacylproline Aminopeptidase,  mAmP,  Membrane-Bound Aminopeptidase P,  Membrane-Bound AmP,  Membrane-Bound APP,  Xaa-Pro Aminopeptidase 2,  X-Pro Aminopeptidase 2,  XPNPEP2
Swissprot
Concentration 1 mg/mL
Buffer 0.2 μm filtered solution in PBS
Purification Method Protein A
Research Areas Signal Transduction,  Cell Biology,  Metabolism
Clone No. 12G13
Conjugation Unconjugated
Storage This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
Shipping Ice bag
background Aminopeptidase P (APP) is a hydrolase specific for N-terminal imido bonds, which are common to several collagen degradation products, neuropeptides, vasoactive peptides, and cytokines. A membrane-bound and soluble form of this enzyme (XPNPEP2) have been identified as products of two separate genes. XPNPEP2, the X-linked gene that encodes membranous aminopeptidase P (APP), has been reported to associate with APP activity. The membrane aminopeptidase P (XPNPEP2) is largely limited in distribution to endothelia and brush border epithelia. APP and XPNPEP2 contain homologous blocks of sequence common to members of the "pita bread-fold" protein family, of which Escherichia coli methionine aminopeptidase is the prototype. The C-2399A variant in XPNPEP2 is associated with reduced APP activity and a higher incidence of AE-ACEi. XPNPEP2 mRNA was detected in fibroblasts that carry the translocation, suggesting that this gene at least partially escapes X inactivation. XPNPEP2 is a candidate gene for premature ovarian failure (POF).
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