Recombinant Uteroglobin/SCGB1A1 Monoclonal Antibody (AN300504P)
For research use only.
| Verified Samples | Verified Samples in IHC: Mouse lung |
| Dilution | IHC-P 1:100-1:500 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Mouse |
| Applications | IHC-P |
| Clonality | Monoclonal |
| Immunogen | Recombinant Mouse Uteroglobin/SCGB1A1 protein |
| Abbre | SCGB1A1 |
| Synonyms | Secretoglobin family 1A member, SCGB1A, CC16, CCPBP, CCSP, Clara cell 17 kDa protein, Clara cell phospholipid-binding protein, Clara cells 10 kDa secretory protein, PCB-binding protein, PCB-BP, Secretoglobin family 1A member 1, UG, UGL, UP1, UP-1, Uteroglobin, Cc10, Ugb, Utg, Scgb1a1 |
| Swissprot | |
| Tissue Specificity | Clara cells (nonciliated cells of the surface epithelium of the pulmonary airways). |
| Concentration | 1 mg/mL |
| Buffer | 0.2 μm filtered solution in PBS |
| Purification Method | Protein A |
| Clone No. | 8C8 |
| Conjugation | Unconjugated |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
| Shipping | Ice bag |
| background | Uteroglobin (UG), also known as Secretoglobin 1A member 1 (SCGB1A1), Blastokinin, Clara cell secretor protein (CCSP) or Clara cell-specific 10-kDa protein (CC10), is the founding member of the secretoglobin family of small, secreted, disulfide-bridged dimeric proteins found only in mammals. This protein is mainly expressed in lung, with anti-inflammatory/immunomodulatory properties. Previous in vitro studies demonstrated that CCAAT/enhancer-binding proteins (C/EBPs) are the major transcription factors for the regulation of SCGB1A1 gene expression, whereas FOXA1 had a minimum effect on the transcription. Uteroglobin is a multifunctional protein with antiinflammatory/immunomodulatory properties. Uteroglobin inhibits soluble phospholipase A(2) activity and binds and perhaps sequesters hydrophobic ligands such as progesterone, retinols, polychlorinated biphenyls, phospholipids, and prostaglandins. In addition to its antiinflammatory activities, Uteroglobin manifests antichemotactic, antiallergic, antitumorigenic, and embryonic growth-stimulatory activities. The tissue-specific expression of the Uteroglobin gene is regulated by several steroid hormones, although a nonsteroid hormone, prolactin, further augments its expression in the uterus. Based on its anti-inflammatory and antiallergic properties, Uteroglobin is a potential drug target. The mechanism of Uteroglobin action is likely to be even more complex as it also functions via a putative receptor-mediated pathway. |
Other Clones
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Unconjugated
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