Recombinant Trk A Monoclonal Antibody (AN301287L)
For research use only.
| Verified Samples | Verified Samples in IHC: Human brain |
| Dilution | IHC 1:2000-1:10000 |
| Isotype | IgG,κ |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC |
| Clonality | Monoclonal;Recombinant |
| Immunogen | Recombinant Human Trk A protein |
| Abbre | Trk A |
| Synonyms | NTRK, NTRK1, MTC, TRK, TRK1, TRKA, Trk-A, p140-TrkA, gp140trk, High affinity nerve growth factor receptor, High affinity nerve growth factor receptor precursor, Neurotrophic tyrosine kinase receptor type 1, Oncogene TRK, p140 TrkA, p14-TrkA, Slow nerve growth, Trk A, TRK1-transforming tyrosine kinase protein, Tropomyosin-related kinase A, Tyrosine kinase receptor, Tyrosine kinase receptor A, Trk A |
| Swissprot | |
| Cellular Localization | Cell membrane, Single-pass type I membrane protein, Early endosome membrane, Single-pass type I membrane protein, Late endosome membrane, Single-pass type I membrane protein, Recycling endosome membrane, Single-pass type I membrane protein, Rapidly internalized after NGF binding (PubMed:1281417). Internalized to endosomes upon binding of NGF or NTF3 and further transported to the cell body via a retrograde axonal transport. Localized at cell membrane and early endosomes before nerve growth factor (NGF) stimulation. Recruited to late endosomes after NGF stimulation. Colocalized with RAPGEF2 at late endosomes. |
| Concentration | 0.2 mg/mL |
| Buffer | PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant. |
| Purification Method | Protein A |
| Research Areas | Neuroscience, Cancer, Metabolism |
| Clone No. | 4D4 |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | Ice bag |
| background | This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. |
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Unconjugated
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