Recombinant TGF β Receptor II Monoclonal Antibody (AN301373L)
For research use only.
| Verified Samples | Verified Samples in WB: Mouse lung |
| Dilution | WB 1:1000-1:5000 |
| Isotype | IgG,κ |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| Clonality | Monoclonal;Recombinant |
| Immunogen | Recombinant Human TGF β Receptor II protein |
| Abbre | TGF β Receptor II |
| Synonyms | MFS, LDS, FAA, AAT, TAAD, TGFR, TGF-beta receptor type, TGFBR, AAT3, FAA3, LDS1B, LDS2, LDS2B, MFS2, RIIC, TAAD2, TGFR-2, TGFbeta-RII, TGF beta Receptor II, TGFBR2, TGF-beta receptor type-2, TGF-beta type II receptor, Transforming growth factor-beta receptor type II, FAA3, LDS1B, LDS2, LDS2B, MFS2, RIIC, TAAD2, Tgfbr2, beta receptor II (70/80kDa), beta receptor II alpha, beta receptor II beta, beta receptor II delta, beta receptor II epsilon, beta receptor II gamma, TbetaR II, TbetaR-II, TBRII, TBR-ii, TGF beta receptor type 2, TGF beta receptor type II, TGF beta receptor type IIB, TGF beta type II receptor, TGFB R2, TGFbeta - RII, TGF-beta receptor type II, TGFbeta RII, TGF-beta-R2, TGFR2, Transforming growth factor, transforming growth factor beta receptor 2, Transforming growth factor beta receptor II, Transforming growth factor beta receptor type II, Transforming growth factor beta receptor type IIC |
| Swissprot | |
| Calculated MW | 65 kDa |
| Observed MW |
65 kDa
Western blotting is a method for detecting a certain protein in a complex sample based on the specific binding of antigen and antibody. Different proteins can be divided into bands based on different mobility rates. The mobility is affected by many factors, which may cause the observed band size to be inconsistent with the expected size. The common factors include: 1. Post-translational modifications: For example, modifications such as glycosylation, phosphorylation, methylation, and acetylation will increase the molecular weight of the protein. 2. Splicing variants: Different expression patterns of various mRNA splicing bodies may produce proteins of different sizes. 3. Post-translational cleavage: Many proteins are first synthesized into precursor proteins and then cleaved to form active forms, such as COL1A1. 4. Relative charge: the composition of amino acids (the proportion of charged amino acids and uncharged amino acids). 5. Formation of multimers: For example, in protein dimer, strong interactions between proteins can cause the bands to be larger. However, the use of reducing conditions can usually avoid the formation of multimers. If a protein in a sample has different modified forms at the same time, multiple bands may be detected on the membrane. |
| Cellular Localization | Membrane |
| Concentration | 0.2 mg/mL |
| Buffer | PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant. |
| Purification Method | Protein A |
| Research Areas | Signal Transduction, Stem Cells |
| Clone No. | 6F2 |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | Ice bag |
| background | This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. |
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