Recombinant Syndecan-4/SDC4 Monoclonal Antibody (AN300551P)
For research use only.
| Verified Samples | Verified Samples in IF: Mouse spleen |
| Dilution | ICC/IF 1:20-1:100 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Mouse |
| Applications | ICC/IF |
| Clonality | Monoclonal |
| Immunogen | Recombinant Mouse SDC4/Syndecan-4 protein |
| Abbre | SDC4 |
| Synonyms | SDC, syndecan, AA959608, Amphiglycan, AW108331, Ryudocan, Ryudocan core protein, SYND4, syndecan-4, Sdc4 |
| Swissprot | |
| Tissue Specificity | Ubiquitous. Highest levels in liver, kidney and lung. |
| Concentration | 1 mg/mL |
| Buffer | 0.2 μm filtered solution in PBS |
| Purification Method | Protein A |
| Clone No. | 5F2 |
| Conjugation | Unconjugated |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
| Shipping | Ice bag |
| background | SDC4 (Syndecan-4), also known as Syn4, is a transmembrane heparan sulfate proteoglycan that co-operates with integrins during cell-matrix interactions for the assembly of focal adhesions and actin stress fibers and in the phosphorylation of focal adhesion kinase (FAK) on Tyr397. Syndecan-4 plays roles in the formation of focal adhesions and stress fibers. The cytoplasmic domain of syndecan-4 interacts with several signalling and structural proteins, and both extracellular and cytoplasmic domains are necessary for regulated activation of associated transmembrane receptors. Syndecan-4/SDC4 is a heparan sulfate proteoglycan and works as a coreceptor for various growth factors. SDC4 deficiency limits neointimal formation after vascular injury by regulating vascular smooth muscle cells (VSMCs) proliferation and vascular progenitor cells (VPCs) mobilization. Therefore, SDC4 may be a novel therapeutic target for preventing arterial restenosis after angioplasty. |
Other Clones
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Unconjugated
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