Recombinant Rat IL-28B/IFN-lambda-3 protein (His Tag) (PDER100211)
For research use only.
| Synonyms | Cytokine Zcyto, IL-12 subunit p, ZCYTO, Cytokine Zcyto22, Cytotoxic Lymphocyte Maturation Factor 35 kDa, IFNL4, IFN-Lambda-3, IFN-Lambda-4, IL-12 subunit p35, IL-12A, IL-28B, IL28C, IL-28C, Interferon Lambda-3, Interferon Lambda-4, Interleukin-12 subunit alpha, Interleukin-28B, Interleukin-28C, ZCYTO22, Il28, Il28b, Ifnl3 |
| Species | Rat |
| Expression Host | E.coli |
| Sequence | His19-Ala192 |
| Accession | F1M3K4 |
| Calculated Molecular Weight | 19.0 kDa |
| Observed Molecular Weight | 26 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
| Purity | > 95% as determined by reducing SDS-PAGE. |
| Endotoxin | < 10 EU/mg of the protein as determined by the LAL method |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis. |
| Background | Interleukin-28B, also known as Cytokine Zcyto22, Interferon lambda-3, Interferon lambda-4, IFNL3, IFNL4, ZCYTO22 and IL28B, is a secreted cytokine which belongs to the IL-28/IL-29 family. IL-28 has also been shown to play a role in the adaptive immune response. IL28B has immunomodulatory activity and up-regulates MHC class I antigen expression. IL28B displays potent antiviral activity and antitumor activity. In addition, IL28B is a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway. |
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