Recombinant Podoplanin/PDPN Monoclonal Antibody (AN300498P)
For research use only.
| Verified Samples | Verified Samples in IHC: Mouse kidney, Mouse brain |
| Dilution | IHC-P 1:250-1:1000 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Mouse |
| Applications | IHC-P |
| Clonality | Monoclonal |
| Immunogen | Recombinant Mouse Podoplanin/PDPN Protein |
| Abbre | PDPN |
| Synonyms | Glycoprotein, RANDAM, Aggrus, Glycoprotein 38, OTS-8, PA2.26 antigen, Podoplanin, RANDAM-2, T1a, T1alpha, T1-alpha, Gp38, Ots8, Pdpn |
| Swissprot | |
| Tissue Specificity | Detected at high levels in lung and brain, at lower levels in kidney, stomach, liver, spleen and esophagus, and not detected in skin and small intestine. Expressed in epithelial cells of choroid plexus, ependyma, glomerulus and alveolus, in mesothelial cells and in endothelia of lymphatic vessels. Also expressed in stromal cells of peripheral lymphoid tissue and thymic epithelial cells. Detected in carcinoma cell lines and cultured fibroblasts. Expressed at higher levels in colon carcinomas than in normal colon tissue. |
| Concentration | 1 mg/mL |
| Buffer | 0.2 μm filtered solution in PBS |
| Purification Method | Protein A |
| Clone No. | 8C2 |
| Conjugation | Unconjugated |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
| Shipping | Ice bag |
| background | Podoplanin, also known as PDPN, is a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined. Alternatively spliced transcript variants encoding different isoforms have been identified.PDPN is a mucin-type glycoprotein negatively charged by extensive O-glycosylation and a high content of sialic acid, which expresses the adhesive property. It is selectively expressed in lymphatic endothelium as well as lymphangiomas, Kaposi sarcomas, and in a subset of angiosarcomas with probable lymphatic differentiation. PDPN may contribute to form odontoblastic fiber or function as the anchorage to the tooth development and in proliferating epithelial cells of cervical loop and apical bud. The intensity of podoplanin expression is negatively correlated with the expression of CD34 and factor VIII. Podoplanin would be useful as a diagnostic marker for epithelioid hemangioendothelioma in liver tumors. |
Other Clones
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Unconjugated
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