Recombinant Phospho-CDK1, 2 (Thr14) Monoclonal Antibody (AN301145L)
For research use only.
| Verified Samples | Verified Samples in IHC: Human colon |
| Dilution | IHC 1:200-1:1000 |
| Isotype | IgG,κ |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC |
| Clonality | Monoclonal;Recombinant |
| Immunogen | A synthetic peptide corresponding to residues around (Thr14) of Human Phospho-CDK1, 2 |
| Abbre | CDK1, 2 |
| Synonyms | CDC, CDK, CDKN, cyclin-dependent kinase, P34CDC, CDK1, CDC2, CDC28A, P34CDC2, cyclin-dependent kinase 1, CDKN1, CDC2, CDC28A, cyclin-dependent kinase 1, P34CDC2, cyclin dependent kinase 1874, CDK1/CDC2 |
| Swissprot | |
| Cellular Localization | Nucleus. Cytoplasm, Mitochondrion, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Cytoplasm, cytoskeleton, spindle. Cytoplasmic during the interphase. Colocalizes with SIRT2 on centrosome during prophase and on splindle fibers during metaphase of the mitotic cell cycle. Reversibly translocated from cytoplasm to nucleus when phosphorylated before G2-M transition when associated with cyclin-B1. Accumulates in mitochondria in G2-arrested cells upon DNA-damage. |
| Concentration | 0.2 mg/mL |
| Buffer | PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant. |
| Purification Method | Protein A |
| Research Areas | Cell Biology, Epigenetics and Nuclear Signaling, Cancer, Neuroscience, Metabolism |
| Clone No. | 6H6 |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | Ice bag |
| background | CDK1(cyclin dependent kinase 1) Homo sapiens The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
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Unconjugated
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