Recombinant OTUB2 Monoclonal Antibody (AN300435P)
For research use only.
| Verified Samples | Verified Samples in IF: A549 |
| Dilution | ICC/IF 1:20-1:100 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | ICC/IF |
| Clonality | Monoclonal |
| Immunogen | Recombinant Human OTUB2 Protein |
| Abbre | OTUB2 |
| Synonyms | OTB, OTU, OTUB, Ubiquitin Thioesterase OTUB, Deubiquitinating Enzyme OTUB, Ubiquitin-Specific-Processing Protease OTUB, OTU Comain-Containing Ubiquitin Aldehyde-Binding Protein, C14orf, Otubain, Deubiquitinating Enzyme OTUB2, OTU Comain-Containing Ubiquitin Aldehyde-Binding Protein 2, Otubain-2, Ubiquitin Thioesterase OTUB2, Ubiquitin-Specific-Processing Protease OTUB2, C14orf137, OTB2, OTU2, OTUB2, FLJ21916, MGC3102, OTU domain, OTU domain containing ubiquitin aldehyde binding protein 2, OTU domain-containing ubiquitin aldehyde-binding protein 2, Otubain 2, ubiquitin aldehyde binding 2, Ubiquitin specific processing protease OTUB2, Ubiquitin specific protease otubain 2 |
| Swissprot | |
| Tissue Specificity | Widely expressed. Expressed at higher level in brain. |
| Concentration | 1 mg/mL |
| Buffer | 0.2 μm filtered solution in PBS |
| Purification Method | Protein A |
| Research Areas | Cell Biology, Epigenetics and Nuclear Signaling, Cancer |
| Clone No. | 4B13 |
| Conjugation | Unconjugated |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
| Shipping | Ice bag |
| background | Otubain 2 (OTUB2) is a member of DUBs that belong to the ovarian tumour (OTU) superfamily of proteins which consists of a five-stranded β-sheet sandwiched in between a small helical amino-terminal region consisting of α1 and α2, and a large helical region comprised of α3-α10. Like other DUBs, otubain 2 (OTUB2) cleaves proteins precisely at the ubiquitin-protein bond so that ubiquitylation process can be reversed and regulated. Otubain 2 (OTUB2)'s active-site cleft is sterically occluded by a novel loop conformation resulting in an oxyanion hole, which consists uniquely of backbone amides. Furthermore, the residues that orient and stabilize the active-site histidine of otubain 2 (OTUB2) are different from other cysteine proteases. This reorganization of the active-site topology provides a possible explanation for the low turnover and substrate specificity of the otubains. |
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Unconjugated
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