Recombinant Neuropilin-1/NRP1/CD304 Monoclonal Antibody (AN300099P)
For research use only.
| Verified Samples | Verified Samples in IHC: Human placenta, Human heart, Human brain |
| Dilution | IHC-P 1:50-1:200, |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | IHC-P |
| Clonality | Rabbit Monoclonal |
| Immunogen | Recombinant Human Neuropilin-1 / NRP1 / CD304 protein |
| Abbre | NRP1 |
| Synonyms | NPN, DKFZp686A, DKFZp781F, BDCA4, CD304, NP1, NRP, VEGF165R, Neuropilin-1, NRP1, ANG, NRP 1, NPN1, BDCA-4, DKFZp686A03134, DKFZp781F1414, Neuropilin1, CD304 antigen, neuropilin 1, Vascular endothelial cell growth factor 165 receptor, neuropilin-1, NRP1, NRPNP1 |
| Swissprot | |
| Cellular Localization | Secreted and Cell membrane. |
| Concentration | 1 mg/mL |
| Buffer | 0.2 μm filtered solution in PBS |
| Purification Method | Protein A |
| Research Areas | Cardiovascular, Neuroscience, Immunology |
| Clone No. | 11G1 |
| Conjugation | Unconjugated |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
| Shipping | Ice bag |
| background | Neuropilin is a type I transmembrane protein and the molecular mass is 120 kDa. Two homologs, Neuropilin-1 and Neuropilin-2, are identified. The primary structure of Neuropilin-1 and Neuropilin-2 is well conserved and is divided into four domains, CUB (a1/a2) domain, FV/FVIII (b1/b2) domain, MAM (c) domain, and (d) domain that contains a transmembrane and a short cytoplasmic region. Neuropilin-1 (NRP1) acts as a receptor for two different extracellular ligands, class 3 semaphorins, and specific isoforms of vascular endothelial growth factor. The functions of NRP1 and NRP2 have been extensively studied in neurons where they act in axon guidance and in endothelial cells where they promote angiogenesis and cell migration. Neuropilin-1 is likely to mediate contacts between the dendritic cells and the T lymphocytes via homotypic interactions and is essential for the initiation of the primary immune response. NRP1 is a co-receptor for VEGF receptor-2 (VEGFR2) that enhances the binding of VEGF165 to VEGFR2 and VEGF165-mediated chemotaxis. NRP1 expression is regulated in EC by tumor necrosis factor-alpha, the transcription factors dHAND and Ets-1, and vascular injury. NRP1 upregulation is positively correlated with the progression of various tumors. Overexpression of NRPI in rat tumor cells results in enlarged tumors and substantially enhanced tumor angiogenesis. On the other hand, soluble NRP1 (sNRP1) is an antagonist of tumor angiogenesis. |
Other Clones
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Unconjugated
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