Recombinant Mouse TPBG/5T4 (C-6His) (PKSM041401)

For research use only.
Synonyms | 5T4 Protein, 5T4AG Protein, Human, M6P1 Protein, WAIF1 Protein |
Species | Mouse |
Expression Host | HEK293 Cells |
Sequence | Ser32-Ser361 |
Accession | Q9Z0L0 |
Calculated Molecular Weight | 36.6 kDa |
Observed Molecular Weight | 50-70 kDa |
Tag | C-His |
Bio-activity | Not validated for activity |
Purity | > 95 % as determined by reducing SDS-PAGE. |
Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.4. |
Reconstitution | Not Applicable |
Background | Trophoblast glycoprotein, also known as TPBG and 5T4, it belongs to the LRR family of proteins. The C-terminus of LRR N-terminal cap (LRRNT) and LRR 1 are essential for the inhibition of the Wnt signaling pathway. TPBG may function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization. It expressed by all types of trophoblasts as early as 9 weeks of development. In adult tissues, the expression is limited to a few epithelial cell types but is found on a variety of carcinoma. |
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