Recombinant Mouse PCSK9/NARC1 Protein (His Tag) (PKSM041128)
For research use only.
| Synonyms | FH3, HCHOLA3, NARC-1, Narc1, Neural Apoptosis-Regulated Convertase 1, PC9, Pcsk9, Proprotein Convertase 9, Proprotein Convertase Subtilisin/Kexin Type 9, Subtilisin/Kexin-Like Protease PC9 |
| Species | Mouse |
| Expression Host | HEK293 Cells |
| Sequence | Gln35-Gln155&Ser156-Gln694 |
| Accession | Q80W65 |
| Calculated Molecular Weight | 14&58.2 kDa |
| Observed Molecular Weight | 19&60 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 50mM HEPES, 150mM NaCl, 20% Glycerol, pH 7.4. |
| Reconstitution | Not Applicable |
| Background | Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER , the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis.PCSK9 also plays a role in neural development. |
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