Recombinant Mouse NTPDase 2/ENTPD2 Protein (His Tag) (PKSM041340)
For research use only.
| Synonyms | Ecto-Nucleoside Triphosphate Diphosphohydrolase 2, Ectonucleoside triphosphate diphosphohydrolase 2, Entpd2 |
| Species | Mouse |
| Expression Host | HEK293 Cells |
| Sequence | Cys26-Ser462 |
| Accession | O55026 |
| Calculated Molecular Weight | 49.2 kDa |
| Observed Molecular Weight | 63-90 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 50mM Tris-HCl, 10mM CaCl2, 150mM NaCl, 10% Glycerol, pH 7.5. |
| Reconstitution | Not Applicable |
| Background | CD39L1 protein (ENTPD2 or NTPDase2) is a member of the ecto-nucleoside triphosphate diphosphohydrolase family which the main role is termination of purinergic signaling. CD39L1 gene encodes a precursor protein with 495 amino acid residues which generates a 437 amino acid residues mature protein after processing. It is an ecto-nucleotidase that found on the surface of vascular adventitial cells and accessory vascular cells. CD39L1 is a Ca2+- and Mg2+-dependent enzyme that activates platelets by preferentially converting ATP to ADP. CD39L1 plays a role in regulating thrombosis and inflammation which is considered to be a therapeutic target for thromboregulation and the treatment of vascular inflammation. Alternative splicing of CD39L1 gene results in multiple transcript variants. |
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