Recombinant Mouse Interleukin-10/IL-10 Protein (PKSM041066)
For research use only.
| Synonyms | Interleukin, IL-, CSIF, If2a, Il-10, IL10A, TGIF, Interleukin-10, IL10, Cytokine synthesis inhibitory factor, N/A, CSIF, If2a, Il-10 |
| Species | Mouse |
| Expression Host | E.coli |
| Sequence | Ser19-Ser178 |
| Accession | P18893 |
| Calculated Molecular Weight | 19.7 kDa |
| Observed Molecular Weight | 19 kDa |
| Tag | C-His |
| Bio-activity | Measure by its ability to induce MC/9‑2 cells proliferation.The ED50 for this effect is <1 ng/mL.The specific activity of recombinant mouse IL-10 is > 1 x 106 IU/mg. |
| Purity | > 98 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 0.1 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation |
Lyophilized from sterile PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
| Background | Mouse Il10 is the prototypic member of the IL-10 cytokine family, including IL-10, IL-19, IL-20, IL-22 (IL-TIF), IL-24 and IL-26. Many viruses encode viral members of the IL-10 family, such as Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV).Its main function is inhibiting the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells. Although human and mouse IL-10 are 81% identical at the nucleotide and amino acid level, mouse IL-10 is species-specific and does not act on human cells. Interestingly, Human IL-10 is active on mouse cells. |
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