Recombinant Mouse IL1RL1/ST2 Protein (Fc Tag) (PKSM041051)
For research use only.
| Synonyms | STE, DER, Fit, Protein T, Protein ST, Lymphocyte antigen, Interleukin-1 receptor-like, suppression of tumorigenicity, IL1RL, IL-1 R, IL-1RL, DER4, Fit-1, IL-1 R4, IL-1RL1, IL-33R, Interleukin-1 receptor-like 1, Lymphocyte antigen 84, Protein ST2, Protein T1, ST2L, ST2V, suppression of tumorigenicity 2, Ly84, St2, Ste2, Il1rl1 |
| Species | Mouse |
| Expression Host | HEK293 Cells |
| Sequence | Ser27-Ala337(Val192Ala) |
| Accession | P14719-2 |
| Calculated Molecular Weight | 62.7 kDa |
| Observed Molecular Weight | 90-110 kDa |
| Tag | C-Fc |
| Bio-activity | Immobilized Mouse IL-33(Cat: PKSM041090) at 5μg/ml(100 μl/well) can bind Mouse ST2-Fc. The ED50 of Mouse ST2-Fc is 0.25ug/ml. |
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation |
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
| Background | ST2, also called IL-1 R4, is an Interleukin-1 receptor family glycoprotein that plays a role in Th2 immune responses. ST2 is expressed on the surface of mast cells, activated Th2 cells, macrophages, and cardiac myocytes. This receptor is very similar to the IL-1 receptor type I and the IL-18 receptor α chain in that ST2 also has three extracellular Ig domains and an intracellular Toll domain. ST2 binds IL-33, enhances inflammatory cytokines by activating nuclear factor-κB (NF-κB) and mitogen activated protein (MAP) kinases. ST2 exists as either a membrane bound form (ST2L) or as a soluble form (sST2). ST2L acts as a transmembrane signalling receptor for IL-33 by mediating the effect of IL-33 on the inflammatory process, while sST2 can suppress IL-33 activity. |
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