Recombinant Mouse IL1R1/CD121a Protein (Fc Tag) (PKSM041047)
For research use only.
| Synonyms | D2S, Interleukin-1 receptor type, IL1-R, mIL-1R, CD121 antigen-like family member A, CD121a, CD121b, D2S1473, IL-1 RI, IL1R, Il1r-1, IL1-R1, IL-1R-1, IL-1R-alpha, IL-1RT1, IL-1RT-1, IL-iR, Interleukin-1 receptor alpha, Interleukin-1 receptor type 1, mIL-1R1, P80, Il-1r1, Il1ra, Il1r1, IL-1R type I, IL1R, Interleukin 1 receptor, interleukin 1 receptor type 1, mIL-1R1, type I |
| Species | Mouse |
| Expression Host | HEK293 Cells |
| Sequence | Leu20-Lys338 |
| Accession | P13504 |
| Calculated Molecular Weight | 64.0 kDa |
| Observed Molecular Weight | 85-110 kDa |
| Tag | C-Fc |
| Bio-activity | Not validated for activity |
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation |
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
| Background | Mouse Interleukin-1 receptor type 1/IL-1 RI is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein is a receptor for interleukin 1 alpha (IL1A), interleukin 1 beta (IL1B), and interleukin 1 receptor antagonist (IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses. An IL1 receptor accessory protein that can heterodimerize with the Type I receptor in the presence of IL1α or IL1βbut not IL1ra, was identified. This Type I receptor complex appears to mediate all the known IL1 biological responses. The receptor Type II has a short cytoplasmic domain and does not transduce IL1 signals. In addition to the membranebound form of IL1 RII, a naturallyoccurring soluble form of IL1 RII has been described. It has been suggested that the Type II receptor, either as the membranebound or as the soluble form, serves as a decoy for IL1 and inhibits IL1 action by blocking the binding of IL1 to the signaling Type I receptor complex. |
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