Recombinant Mouse IL-33 Protein(Trx Tag) (PDEM100206)
For research use only.
| Synonyms | DVS, NF-HEV and IL- 1F, Interleukin-1 family member, C9orf, C9orf26, DVS27, Interleukin-1 family member 11, NF-HEV and IL- 1F11, NKHEV, IL33, Interleukin-33, IL-33, Interleukin 33, IL1F11, NFEHEV, NF-HEV |
| Species | Mouse |
| Expression Host | E.coli |
| Sequence | Gln109-Ile266 |
| Accession | Q8BVZ5 |
| Calculated Molecular Weight | 37.4 kDa |
| Observed Molecular Weight | 37 kDa |
| Tag | N-Trx |
| Bio-activity | Not validated for activity |
| Purity | > 95% as determined by reducing SDS-PAGE. |
| Endotoxin | < 10 EU/mg of the protein as determined by the LAL method |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis |
| Background | Interleukin 33 (IL-33), also known as DVS27 or NF-HEV (Nuclear Factor from High Endothelial Venules), is a pro-inflammatory protein and a chromatin-associated cytokine of the IL-1 family with high sequence and structural similarity to IL-1 and IL-18. IL-33 protein is expressed highly and rather selectively by high endothelial venule endothelial cells (HEVECs) in human tonsils, Peyer's patches, and lymph nodes. IL-33 protein has transcriptional regulatory properties, and the researches suggested that IL-33 is a dual-function protein that might act both as a cytokine and as an intracellular nuclear factor. As a type 2 cytokines, IL-33 protein also play a pivotal role in helminthic infection and allergic disorders. |
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