Recombinant Mouse IGFBP-2 Protein(Sumo Tag) (PDEM100183)
For research use only.
| Synonyms | IGF-binding protein, Insulin-like growth factor-binding protein, IGF-BP, mIGFBP, IBP2, IBP-2, IGF-binding protein 2, IGF-BP53, Insulin-like growth factor-binding protein 2, mIGFBP-2, Igfbp-2, Igfbp2, AI255832 |
| Species | Mouse |
| Expression Host | E.coli |
| Sequence | Glu35-Gln305 |
| Accession | P47877 |
| Calculated Molecular Weight | 42.7 kDa |
| Observed Molecular Weight | 45 kDa |
| Tag | N-Sumo |
| Bio-activity | Not validated for activity |
| Purity | > 90% as determined by reducing SDS-PAGE. |
| Endotoxin | < 10 EU/mg of the protein as determined by the LAL method |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis. |
| Background | IGFBP-2, also known as IGFBP-2, is an insulin-like growth factor-binding protein (IGFBP). IGFBPs prolong the half-life of the IGFs, control bioavailability, activity, and distribution of insulin-like growth factor (IGF) throμgh high-affinity IGFBP/IGF complexes. Six high-affinity IGF-binding proteins (IGFBP-1 to-6) have been identified. The six IGFBPs are structurally related but encoded by distinct genes. IGFBPs have a high affinity for IGFs. Some members of the IGFBP family have been consistently shown to inhibit IGF actions by preventing them from gaining access to the IGF receptors, while others potentiate IGF actions by facilitating the ligand-receptor interaction. IGFBP-2 is overexpressed in many malignancies and is often correlated with an increasingly malignant status of the tumor, pointing to the potential involvement of IGFBP-2 in tumorigenesis. It contains 1 IGFBP N-terminal domain and 1 thyroglobulin type-1 domain. It inhibits IGF-mediated growth and developmental rates. |
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