Recombinant Mouse Granzyme B(G,H)/GZMB Protein (His Tag) (PKSM041035)
For research use only.
| Synonyms | CCP1, CTLA-1, Ctla-1, Ctla1, Cytotoxic cell protease 1, Fragmentin-2, Granzyme B(G,H), Gzmb |
| Species | Mouse |
| Expression Host | HEK293 Cells |
| Sequence | Gly19-Ser247 |
| Accession | P04187 |
| Calculated Molecular Weight | 26.5 kDa |
| Observed Molecular Weight | 35 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.4. |
| Reconstitution | Not Applicable |
| Background | Granzyme B(GZMB) contains 1 peptidase S1 domain and belongs to the peptidase S1 family. This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp and seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. The protein cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis. |
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