Recombinant Mouse Fetuin A/AHSG Protein(Fc Tag) (PDMM100139)
For research use only.
| Synonyms | KUB, SGP, TRPM, NA1/NA, A2HS, AHS, alpha-2-HS-glycoprotein, APOJ, APO-J, CLI, Countertrypin, Fetuin-A, HSGA, KUB1, NA1/NA2, SGP2, SP-40, TRPM2, Fetua, Ahsg |
| Species | Mouse |
| Expression Host | Mammalian |
| Sequence | Ala19-Ile345 |
| Accession | P29699 |
| Calculated Molecular Weight | 57.6 kDa |
| Observed Molecular Weight | 70-80 kDa |
| Tag | C-Fc |
| Bio-activity | Not validated for activity |
| Purity | > 90% as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU/mg of the protein as determined by the LAL method |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis. |
| Background | Fetuin-A , also known as Alpha-2-HS-Glycoprotein (AHSG) , belongs to the Fetuin family , is a plasma binding protein , and is more abundant in fetal than adult blood. It is involved in several functions , such as endocytosis , brain development and the formation of bone tissue. Fetuins are carrier proteins like albumin. Fetuin-A forms soluble complexes with calcium and phosphate and thus is a carrier of otherwise insoluble calcium phosphate. Thus Fetuin-A is a potent inhibitor of pathological calcification. The circulating levels of fetuin-A , a well-described inhibitor of calcification , regulate the cell-dependent process of osteogenesis. The low circulating fetuin-A levels are associated with a greater prevalence and/or severity of Vascular calcification (VC) and increased risk for all-cause and cardiovascular mortality. However , high circulating fetuin-A levels appear to induce insulin resistance and , in non-dialyzed subjects with diabetic nephropathy , are directly related to VC burden. The emerging role of fetuin-A deficiency as a risk factor in dialysis patients was documented in cross-sectional studies demonstrating a significant correlation with all-cause and cardiovascular mortality. Additionally , Human fetuin-A is a negative acute phase protein involved in inflammatory diseases , thus being a potential physiological regulator of meprin activity. Fetuin-A is a broad-range protease inhibitor. Fetuin-A and cystatin C as endogenous proteolytic regulators of meprin activity broadens our understanding of the proteolytic network in plasma. |
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