Recombinant Mouse CXCL1 Protein(Trx Tag) (PDEM100202)
For research use only.
| Synonyms | CXCL, SCYB, Secretory protein N, Neutrophil-Activating Protein, GROα/CXCL, C-X-C Motif Chemokine 1, GRO-A, GRO-Alpha(1-73), Growth-Regulated Alpha Protein, GROα/CXCL1, Melanoma Growth Stimulatory Activity, NAP3, Neutrophil-Activating Protein 3, Platelet-derived growth factor-inducible protein KC, Secretory protein N51, CINC1, CINC-1, CXCL1, FSP, GRO1, GROa, KC, MGSA, MGSA-a, MGSA-alpha, NAP-3, SCYB1, GRO alpha, Growth Regulated Oncogene Alpha, Gro |
| Species | Mouse |
| Expression Host | E.coli |
| Sequence | Ala25-Lys96 |
| Accession | P12850 |
| Calculated Molecular Weight | 27.9 kDa |
| Observed Molecular Weight | 28 kDa |
| Tag | N-Trx |
| Bio-activity | Not validated for activity |
| Purity | > 95% as determined by reducing SDS-PAGE. |
| Endotoxin | < 10 EU/mg of the protein as determined by the LAL method |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis |
| Background | CXCL1 is a potent neutrophil chemoattractant with recognized roles in angiogenesis and inflammation. CXCL1 is a novel immediate PTH/PTHrP-responsive gene. CXCL1 may act as a chemoattractant for osteoclast precursors. CXCL1 may also have important pro-nociceptive effects via its direct actions on sensory neurons, and may induce long-term changes that involve protein synthesis. CXCL1 plays a critical nonredundant role in the development of experimental Lyme arthritis and carditis via CXCR2-mediated recruitment of neutrophils into the site of infection. CXCL1 functions through CXCR2 to transactivate the EGFR by proteolytic cleavage of HB-EGF, leading to activation of MAPK signalling and increased proliferation of epithelial ovarian cancer (EOC) cells. It might limit tumor growth by reinforcing senescence early in tumorigenesis. Thus, CXCL1 plays a role in spinal cord development by inhibiting the migration of oligodendrocyte precursors and is involved in the processes of angiogenesis, inflammation, wound healing, and tumorigenesis. |
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