Recombinant Mouse CTLA4/CD152 Protein (His Tag) (PKSM040643)
For research use only.
| Synonyms | Cd152, Ctla-4, Ly-56 |
| Species | Mouse |
| Expression Host | HEK293 Cells |
| Sequence | Met 1-Phe 162 |
| Accession | NP_033973.2 |
| Calculated Molecular Weight | 15.3 kDa |
| Observed Molecular Weight | 25-30 kDa |
| Tag | C-His |
| Bio-activity | 1. Immobilized recombinant mouse CTLA4-His at 10 μg/ml (100 μl/well) can mouse CD80-Fc with a linear range of 0.78-62. 5 ng/ml. 2. Immobilized recombinant mouse CTLA4-His at 10 μg/ml (100 μl/well) can human B7-1-Fc with a linear range of 0.78-125 ng/ml. |
| Purity | > 98 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation |
Lyophilized from sterile PBS, pH 7.4 Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
| Background | Cytotoxic T-lymphocyte protein 4, also known as CTLA4 and CD152, is a single-pass type I membrane protein and a member of the immunoglobulin superfamily. It is the second member of the CD28 receptor family. The ligands or counterreceptors for these two proteins are the B7 family members, CD80 (B7-1) and CD86 (B7-2). CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may play an important role in their functions. CD152 or cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential receptor involved in the negative regulation of T cell activation. Because of its profound inhibitory role, CD152 has been considered a sound susceptible candidate in autoimmunity and a persuasive target for cancer immunotherapy. In particular, recent evidence suggests that CD152 is also important in the homeostasis and function of a population of suppressive cells, termed regulatory T cells (Treg). |
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