Recombinant Mouse CD80/B7-1 Protein (Fc Tag) (PKSM040680)
For research use only.
| Synonyms | Activation B7-1 antigen, B7, CD80, Cd28l, Ly-53, Ly53, MIC17, T-lymphocyte activation antigen CD80, TSA1 |
| Species | Mouse |
| Expression Host | HEK293 Cells |
| Sequence | Met 1-Lys 245 |
| Accession | Q00609-1 |
| Calculated Molecular Weight | 50.7 kDa |
| Tag | C-hFc |
| Bio-activity | Immobilized human CTLA4 at 10 μg/mL (100 μl/well) can bind mouse CD80-Fc, The EC50 of mouse CD80-Fc is 28 ng/mL. |
| Purity | > 90 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation |
Lyophilized from sterile PBS, pH 7.4 Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
| Background | The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. As costimulatory ligands, B7-1 which exists predominantly as dimer and the related protein B7-2, interact with the costimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus constitute one of the dominant pathways that regulate T cell activation and tolerance, cytokine production, and the generation of CTL. The B7/CD28/CTLA4 pathway has the ability to both positively and negatively regulate immune responses. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas. |
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