Recombinant Mouse CD300a/LMIR1 Protein (Fc Tag) (PKSM041101)
For research use only.
| Synonyms | CD300 antigen-like family member A, CD300a, CD300a antigen, CD300a molecule, CLM8, CMRF-35H, CMRF35-like molecule 8, CMRF35H9, IRp60, Immunoglobulin superfamily member 12, Inhibitory receptor protein 60, NK inhibitory receptor, leukocyte immunoglobulin-like receptor |
| Species | Mouse |
| Expression Host | HEK293 Cells |
| Sequence | Leu28-Arg183 |
| Accession | Q6SJQ0 |
| Calculated Molecular Weight | 44.3 kDa |
| Observed Molecular Weight | 58-75 kDa |
| Tag | C-Fc |
| Bio-activity | Not validated for activity |
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation |
Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
| Background | LMIR1, also termed CD300a, is a type I transmembrane glycoprotein with a single IgV-like extracellular domain and an extended membrane proximal region that links the immunoglobulin (Ig) and transmembrane domains and belongs to the immunoglobulin superfamily. The intracellular domain of LMIR1 contains several immunoreceptor tyrosine-based inhibition motifs (ITIMs). When cross-linked, it will be tyrosine phosphorylated and capable of recruiting tyrosine phosphatases (SHP-1, SHP-2) and inositol polyphosphate 5-phosphatase, SHIP. LMIR1 will regulate mast cell-mediated inflammatory responses. LMIR1 is broadly expressed on myeloid and lymphoid cells, and its expression is differentially regulated depending on the cell type. |
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