Recombinant Mouse Ccl24 Protein(Trx Tag) (PDEM100130)
For research use only.
| Synonyms | C-C motif chemokine 24, CCL24, CCL24, Chemokine CC Motif Ligand 24, CK beta 6, CK-beta-6, Ckb6, Eosinophil chemotactic protein 2, Eotaxin-2, MPIF-2, MPIF2, Myeloid progenitor inhibitory factor 2, SCYA24, Small inducible cytokine subfamily A (Cys-Cys) member 24, Small-inducible cytokine A24 |
| Species | Mouse |
| Expression Host | E.coli |
| Sequence | Val27-Val119 |
| Accession | Q9JKC0 |
| Calculated Molecular Weight | 30.1 kDa |
| Observed Molecular Weight | 33 kDa |
| Tag | N-Trx |
| Bio-activity | Not validated for activity |
| Purity | > 90% as determined by reducing SDS-PAGE. |
| Endotoxin | < 10 EU/mg of the protein as determined by the LAL method |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis. |
| Background | CCL24, also known as Eotaxin-2 and MPIF-2, belongs to the intercrine beta (chemokine CC) family. CCL24 gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. CCL24 displays chemotactic activity on resting T lymphocytes, a minimal activity on neutrophils, and is negative on monocytes and activated T lymphocytes. CCL24 is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. CCL24 is chemotactic for resting T-lymphocytes, and eosinophils. It has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. It is a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. Eotaxin-2 interacts with an chemokine receptor CCR3 to induce chemotaxis in eosinophils. Elevated level of Eotaxin-2 has been seen in patients with an aspirin-exacerbated respiratory disease. |
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