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Recombinant Mouse Carbonic Anhydrase 4/CA4 Protein (aa 18-277, His Tag) (PKSM040973)

All Size Price Qty
50μg $ 358.00
10μg $ 158.00
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For research use only.

Synonyms CA-IV, CA4, CAIV, Car4, Carbonate dehydratase IV, EC4.2.1.1, RP17, carbonic anhydrase 4, carbonic anhydrase IVRP17, carbonic dehydratase IV, retinitis pigmentosa 17
Species Mouse
Expression Host HEK293 Cells
Sequence Glu18-Ser277
Accession Q64444
Calculated Molecular Weight 30.5 kDa
Observed Molecular Weight 36 kDa
Tag C-His
Bio-activity Not validated for activity
Form Liquid
Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0.
Background Carbonic anhydrase 4(CA4) is an enzyme that belongs to the alpha-carbonic anhydrase family. CA4 consists of a signal peptide (residues1-17), an ectodomain (residues18-277) and a propeptide (residues278-305), which is removed in the mature form. it is predominantly expressed in the embryo. CA4 can catalyzes the reversible reaction of CO2+H2O=HCO3-+H+, and stimulates the sodium/bicarbonate transporter activity of SLC4A4. Studies have shown that this protein have a role in inherited renal abnormalities of bicarbonate transport. Alpha-carbonic anhydrase family participate in avariety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor. They show extensive diversity in tissue is attribution and in their sub cellular localization.
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