Recombinant Human XPNPEP2 Protein (His Tag) (PKSH033349)

For research use only.
Synonyms | Aminoacylproline Aminopeptidase, Membrane-Bound APP, Membrane-Bound AmP, Membrane-Bound Aminopeptidase P, X-Pro Aminopeptidase 2, XPNPEP2, Xaa-Pro Aminopeptidase 2, mAmP |
Species | Human |
Expression Host | HEK293 Cells |
Sequence | His22-Ala650 |
Accession | O43895 |
Calculated Molecular Weight | 71.6 kDa |
Observed Molecular Weight | 78 kDa |
Tag | C-His |
Bio-activity | Not validated for activity |
Purity | > 95 % as determined by reducing SDS-PAGE. |
Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0. |
Reconstitution | Not Applicable |
Background | Xaa-Pro aminopeptidase 2 (XPNPEP2) belongs to the peptidase M24B family of metalloproteases. Human XPNPEP2 is widely expressed in various tissues; such as kidney; lung; heart; placenta; liver; small intestine and colon. However; it doesn’t express in brain; skeletal muscle; pancreas; spleen; thymus; prostate; testis and ovary. XPNPEP2 is a Homotrimer which binds 2 manganese ions per subunit. The metalloprotease XPNPEP2 may play a role in the inflammatory process and other reactions produced in response to injury or infection and the metabolism of the vasodilator bradykinin. |
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