Recombinant Human TIMP-2 Protein(hIgG1 Fc Tag) (PDMH100439)
For research use only.
| Synonyms | DDC, TIMP, metalloproteinase inhibitor, TIMP metallopeptidase inhibitor, Tissue inhibitor of metalloproteinases, CSC-21Ktissue inhibitor of metalloproteinase, TIMP2, CSC-21K, DDC8, CSC-21Ktissue inhibitor of metalloproteinase 2, metalloproteinase inhibitor 2, TIMP metallopeptidase inhibitor 2, Tissue inhibitor of metalloproteinases 2, Metalloproteinase inhibitor 2, Metalloproteinase inhibitor 2 precursor, TIMP 2, TIMP metallopeptidase inhibitor 2, TIMP2, Tissue inhibitor of metalloproteinases 2, CSC 21K, CSC-21K, Tissue inhibitor of metalloproteinases 2 (TIMP-2) |
| Species | Human |
| Expression Host | Mammalian |
| Sequence | Cys27-Pro220 |
| Accession | P16035 |
| Calculated Molecular Weight | 46.2 kDa |
| Observed Molecular Weight | 50 kDa |
| Tag | C-hIgG1 Fc |
| Bio-activity | Not validated for activity |
| Purity | > 95% as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU/mg of the protein as determined by the LAL method |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis |
| Background | Tissue inhibitors of metalloproteinases (TIMP) family are natural inhibitors of the matrix metalloproteinases (MMPs), the zinc enzymes involved in extracellular matrix maintenance and remodeling. The TIMP family encompasses four members (TIMP1-4), and they inhibit most MMPs by forming non-covalent binary complex. TIMP2 is a 22 kDa non N-glycosylated protein expressed by a variety of cell types, and plays a unique role among TIMP family members owing to its functions to regulate cellular responses to growth factors. Findings establish an unexpected, MMP-independent mechanism for TIMP2 inhibition of endothelial cell proliferation in vitro and reveal an important component of the antiangiogenic effect of TIMP2 in vivo. TIMP-2 thus is critical to the maintenance of tissue homeostasis and is involved in the regulation of tumor microenvironment. |
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