Recombinant Human TIGIT Protein (Fc Tag) (PKSH033510)
For research use only.
| Synonyms | T-cell immunoreceptor with Ig and ITIM domains, Tigit, V-set and immunoglobulin domain-containing protein 9, V-set and transmembrane domain-containing protein 3, VSIG9, VSTM3 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Met22-Pro141 |
| Accession | Q495A1 |
| Calculated Molecular Weight | 39.7 kDa |
| Observed Molecular Weight | 40-55 kDa |
| Tag | C-Fc |
| Bio-activity | Not validated for activity |
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation |
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
| Background | T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the CD28 family within the Ig superfamily of proteins. TIGIT is expressed on NK cells and subsets of activated; memory and regulatory T cells; and particularly on follicular helper T cells within secondary lymphoid organs. It binds to CD155 and Nectin-2 that appear on dendritic cells (DC) and endothelium. Ligation of TIGIT on T cells down-regulates TCR-mediated activation and subsequent proliferation; while NK cell TIGIT ligation blocks NK cell cytotoxicity. Through CD155 and Nectin-2; which also interact with DNAM-1/CD226 and CD96/Tactile; TIGIT is part of an interacting network of Ig superfamily members that may augment or oppose each other. In particular; TIGIT binding to CD155 can antagonize the effects of DNAM1. |
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