Recombinant Human Tie-2 Protein(His Tag) (PDMH100291)
For research use only.
| Synonyms | TIE, TEK, CD202B, GLC3E, TIE-2, TIE2, VMCM, VMCM1, Tie2 (Tek), Angiopoietin 1 receptor, Angiopoietin-1 receptor, CD202b antigen, endothelial, Endothelial tyrosine kinase, Endothelium specific receptor tyrosine kinase 2, hTIE 2, hTIE2, Hyk, p140 TEK, Soluble TIE2 variant 1, Soluble TIE2 variant 2, tek tyrosine kinase, TEK tyrosine kinase endothelial, TIE 2, Tunica interna endothelial cell kinase, Tyrosine kinase with Ig and EGF homology domains 2, Tyrosine kinase with Ig and EGF homology domains-2, Tyrosine protein kinase receptor TEK, Tyrosine protein kinase receptor TIE 2, Tyrosine-protein kinase receptor TEK, Tyrosine-protein kinase receptor TIE-2, Venous malformations multiple cutaneous and mucosal, VMCM 1 |
| Species | Human |
| Expression Host | Mammalian |
| Sequence | Ala23-Leu748 |
| Accession | Q02763 |
| Calculated Molecular Weight | 104.7 kDa |
| Observed Molecular Weight | 105 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
| Purity | > 90% as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU/mg of the protein as determined by the LAL method |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis. |
| Background | TEK , or TIE-2 , is an endothelial cell-specific receptor tyrosine kinase (RTK) that is known as a functioning molecule of vascular endothelial cells. TEK comprises a subfamily of RTK with TIE , and these two receptors play critical roles in vascular maturation , maintenance of integrity and remodeling. Targeted mutagenesis of both Tek and its agonistic ligand , Angiopoietin-1 , result in embryonic lethality , demonstrating that the signal transduction pathways mediated by this receptor are crucial for normal embryonic development. TEK signaling is indispensable for the development of the embryonic vasculature and suggests that TEK signaling may also be required for the development of the tumor vasculature. |
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