Recombinant Human SNCα Protein(Trx Tag) (PDEH101110)
For research use only.
| Synonyms | Fetal liver kinase, Protein-tyrosine kinase receptor flk, Vascular endothelial growth factor receptor, PD1, NACP, PARK1, PARK4, SNCA, SNC-A, aSYN, CD309, Fetal liver kinase 1, FLK1, FLK-1, KDR, Kinase insert domain receptor, Protein-tyrosine kinase receptor flk-1, Vascular endothelial growth factor receptor 2, VEGFR, VEGFR2, VEGFR-2, Alpha-synuclein, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, PARK1, alpha (non A4 component of amyloid precursor), Alpha synuclein, alphaSYN, isoform NACP140, Lewy body) 4, MGC105443, MGC110988, MGC127560, MGC64356, Non A beta component of AD amyloid, Non A4 component of amyloid, Non A4 component of amyloid precursor, Non-A4 component of amyloid, Non-A-beta component of alzheimers disease amyloid, OTTHUMP00000218549, OTTHUMP00000218551, OTTHUMP00000218552, OTTHUMP00000218553, OTTHUMP00000218554, PARK 1, PARK 4, Parkinson disease (autosomal dominant, Parkinson disease familial 1, precursor of, Snca synuclein, SYN, Synuclein, Synuclein alpha, Synuclein alpha 140, SYUA |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met1-Ala140 |
| Accession | P37840 |
| Calculated Molecular Weight | 35.2 kDa |
| Observed Molecular Weight | 37 kDa |
| Tag | N-Trx |
| Bio-activity | Not validated for activity |
| Purity | > 90% as determined by reducing SDS-PAGE. |
| Endotoxin | < 10 EU/mg of the protein as determined by the LAL method |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis |
| Background | Alpha-Synuclein (SNCA) is a member of the Synuclein family. SNCA is expressed principally in brain but also expressed in low concentrations in all tissues except liver. SNCA interacts with UCHL1, Phospholipase D and histones. SNCA can include beta- and gamma-synuclein. In addition, SNCA is an important regulatory component of vesicular transport in neuronal cells. It has been suggested that SNCA is related to the pathogenesis of Parkinson's Disease and neurodegenerative disorders. Defects in SNCA will lead to Dementia Lewy Body (DLB). |
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