Recombinant Human P21 protein (His Tag) (PDEH100898)
For research use only.
| Synonyms | CAP20, CDK-interacting protein 1, CDKI, CDKN1, CDKN1A, CDN1A, CIP1, Cyclin Dependent Kinase Inhibitor 1A, DNA Synthesis Inhibitor, MDA-6, MDA6, Melanoma differentiation-associated protein 6, P21cip1, P21waf, PIC1, SDI1, SLC12A9, WAF1 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Gly40-Pro164 |
| Accession | P38936 |
| Calculated Molecular Weight | 13.6 kDa |
| Observed Molecular Weight | 18 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
| Purity | > 95% as determined by reducing SDS-PAGE. |
| Endotoxin | < 10 EU/mg of the protein as determined by the LAL method |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis. |
| Background | May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. |
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