Recombinant Human NOL3 Protein (PKSH032827)
For research use only.
| Synonyms | Apoptosis Repressor With CARD, Muscle-Enriched Cytoplasmic Protein, Myp, Nop30, Nucleolar Protein 3, Nucleolar Protein of 30 kDa |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-Ser208 |
| Accession | O60936 |
| Calculated Molecular Weight | 22.6 kDa |
| Observed Molecular Weight | 29 kDa |
| Tag | None |
| Bio-activity | Not validated for activity |
| Purity | > 90 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM PB, 150mm NaCl, 1mM DTT, 1mM EDTA, 10% Glycerol, pH7.0. |
| Reconstitution | Not Applicable |
| Background | Nucleolar protein 3 is encoded by NOL3 gene. Multiple transcript variants encoding different isoforms have been found for this gene. So far; Nucleolar protein 3 has show to have two Isoforms. Isoform 1 may be involved in RNA splicing. Isoform 2 functions as an apoptosis repressor that blocks multiple modes of cell death. It inhibits extrinsic apoptotic pathways through two different ways. Firstly; it by interacting with FAS and FADD upon FAS activation blocking death-inducing signaling complex (DISC) assembly. Secondly by interacting with CASP8 in a mitochondria localization- and phosphorylation-dependent manner; limiting the amount of soluble CASP8 available for DISC-mediated activation. It has been shown to down-regulate the enzyme activities of caspase 2; caspase 8 and tumor protein p53. |
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