Recombinant Human NME1/NDKA Protein (His Tag) (PKSH030357)
For research use only.
| Synonyms | AWD, GAAD, Granzyme A-Activated DNase, Metastasis Inhibition Factor nm23, NB, NBS, NDK A, NDKA, NDP Kinase A, NDPK-A, NDPKA, NM23, NM23-H1, NME1, Nucleoside Diphosphate Kinase A, Tumor Metastatic Process-Associated Protein, nm23-H1 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Ala 2-Glu 152 |
| Accession | NP_000260.1 |
| Calculated Molecular Weight | 18.0 kDa |
| Observed Molecular Weight | 21 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
| Purity | > 98 % as determined by reducing SDS-PAGE. |
| Endotoxin | Please contact us for more information. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as sterile solution of PBS, pH 7.4 |
| Reconstitution | Not Applicable |
| Background | NME1, also known as Nucleoside Diphosphate Kinase A (NDK-A), or NM23-H1, belongs to the NDK family. NM23-H1 is known to have a metastasis suppressive activity in many tumor cells. Recent studies have shown that the interacting proteins with NM23-H1 which mediate the cell proliferation, may act as modulators of the metastasis suppressor activity. The interacting proteins with NM23-H1 can be classified into 3 groups. The first group of proteins can be classified as upstream kinases of NM23-H1 such as CKI and Aurora-A/STK15. The second group of proteins acts as downstream effectors for the regulation of specific gene transcriptions, GTP-binding protein functions, and signal transduction in Erk signal cascade. The third group of proteins can be classified as bi-directionally influencing binding partners of NM23-H1. As a result, the interactions with NM23-H1 and binding partners have implications in the biochemical characterization involved in metastasis and tumorigenesis. NDKA is increased in human postmortem cerebrospinal fluid (CSF), a model of global brain insult, suggesting that measurement in CSF and, more importantly, in plasma may be useful as a biomarker of stroke. Additionally, NM23-H1 significantly reduces metastasis without effects on primary tumor size and was the first discovered metastasis suppressor gene. |
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