Recombinant Human KPNA2 Protein (His Tag) (PKSH032670)
For research use only.
| Synonyms | Importin Subunit Alpha-2, KPNA2, Karyopherin Subunit Alpha-2, RAG Cohort Protein 1, RCH1, SRP1, SRP1-Alpha |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-Phe529 |
| Accession | P52292 |
| Calculated Molecular Weight | 60.0 kDa |
| Observed Molecular Weight | 46-63 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 1mM DTT, 20% Glycerol, pH 8.0. |
| Reconstitution | Not Applicable |
| Background | Karyopherin Subunit α-2 (KPNA2) belongs to the importin alpha family. KPNA2 is widely expressed in many tissues and contains an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. KPNA2 interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination. KPNA2 functions in nuclear protein importantly as an adapter protein for nuclear receptor KPNB1. |
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