Recombinant Human Kallikrein 7/KLK7 Protein (His Tag) (PKSH033421)
For research use only.
| Synonyms | KLK7, Kallikrein-7, PRSS6, SCCE, Serine Protease 6, Stratum Corneum Chymotryptic Enzyme, hK7, hSCCE |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Glu23-His252 |
| Accession | AAH32005 |
| Calculated Molecular Weight | 26.2 kDa |
| Observed Molecular Weight | 30 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM HEPES, 150mM NaCl, pH 7.5. |
| Reconstitution | Not Applicable |
| Background | Human Kallikrein 7 is a member of the tissue kallikrein family of extracellular serine proteases that is made up of 15 members. It is predominantly expressed in the skin. A major physiological function of Kallikrein 7 is to regulate the desquamation process (the shedding of corneocytes from the outer layer of the epidermis) through proteolysis of the intercellular adhesive structures between corneocytes. Dysregulation of Kallikrein 7 has been linked to several inflammatory skin diseases including atopic dermatitis, psoriasis, and Netherton syndrome. Studies have shown that Kallikrein 5 is a potential physiological activator for Kallikrein 7. The proform of Kallikrein 7 can be activated by thermolysin. |
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