Recombinant Human Interleukin-33/IL-33 Protein (His Tag) (PKSH032642)
For research use only.
| Synonyms | DVS, IL1F, Interleukin, C9orf, IL-1F, IL33, C9orf26, DVS27, IL1F11, NF-HEV, NFEHEV, DVS27 related protein, IL-1F11, IL-33, Interleukin-1 family member 11, Interleukin-33, Nuclear factor from high endothelial venules, NFHEV, CHROMOSOME 9 OPEN READING FRAME 26, DKFZp586H0523, IL 1F11, IL 33, Interleukin 1 family member 11, Interleukin 33, INTERLEUKIN 33 NFHEV, Interleukin 33 precursor, Interleukin33, Interleukin-33 (109-270), NF HEV, Nuclear factor for high endothelial venules, OTTHUMP00000021041, RP11 575C20.2 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Ser112-Thr 270 |
| Accession | O95760 |
| Calculated Molecular Weight | 18.9 kDa |
| Observed Molecular Weight | 19 kDa |
| Tag | C-His |
| Bio-activity | Measure by its ability to binding with recombinant ST2L (IL-33 receptor). The ED50 for this effect is <54 ng/mL.Measure by its ability to induce proliferation in D10.G4.1 cells. The ED50 for this effect is < 0.1 ng/mL. The specific activity of recombinant human IL-33 is approximately >4 x107 IU/ mg. |
| Purity | > 98 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 0.1 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation |
Lyophilized from sterile PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
| Background | Interleukin-33 (IL-33) belongs to the IL-1 superfamily. IL33 is highly expressed in endothelial venules found in tonsils; Peyer patches and mesenteric lymph nodes; but almost undetectable in placenta. IL33 induces the production of T helper-2 (Th2)-associated cytokines. IL-33 is a cytokine that mediates its biological effects by binding to and signals through IL1RL1/ST2 and IL-1 Receptor Accessory Protein (IL1RAP); activating intracellular molecules in the NF-κB and MAP kinase signaling pathways that drive production of type 2 cytokines from polarized Th2 cells. |
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