Recombinant Human Interleukin-2/IL-2 Protein (Mutant) (PKSH033625)
For research use only.
| Synonyms | IL2, IL-2, TCGF, lymphokine, Aldesleukin, IL-2lymphokine, interleukin-2, Proleukin, interleukin 2, involved in regulation of T-cell clonal expansion, T cell growth factor, T-cell growth factor, IL 2, IL2, Interleukin 2, interleukin2, Involved in regulation of T cell clonal expansion, Lymphokine, POIL2, T Cell Growth Factor, TCGF |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Ala21-Thr153(L100F,R101D,L105V,I106V,I112F) |
| Accession | P60568 |
| Calculated Molecular Weight | 16.5 kDa |
| Observed Molecular Weight | 16&18 kDa |
| Tag | C-His |
| Bio-activity | Measured in a cell proliferation assay using CTLL‑2 mouse cytotoxic T cells. The ED50 for this effect is 151.39 pg/ml. |
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation |
Lyophilized from a 0.2 μm filtered solution of 4mM HCl. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
| Background | Interleukin-2(IL-2) is an interleukin; a type of cytokine signaling molecule in the immune system;belongs to the IL-2 family. It is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions that are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells; NK cells; lymphokine-activated killer cells; monocytes; macrophages and oligodendrocytes. New research has shown that IL-2 mutant reduced toxicity while being more potent at stimulating anti-tumor effector immune cells. |
Other Clones
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