Recombinant Human IL2RA Protein(Fc Tag) (PDMH100268)
For research use only.
| Synonyms | Interleukin 2 receptor alpha chain, CD25, CD25 antigen, IDDM10, IL 2 receptor alpha subunit, IL-2 receptor subunit alpha, IL-2-RA, IL-2R subunit alpha, IL2 RA, IL2-RA, IL2R, IL2R, alpha chain, IL2RA, IL2RA, IMD41, Interleukin 2 receptor alpha, Interleukin 2 receptor, Interleukin-2 receptor subunit alpha, p55, t-cell growth factor receptor, TAC, TAC antigen, TCGFR |
| Species | Human |
| Expression Host | Mammalian |
| Sequence | Glu22-Gln240 |
| Accession | P01589 |
| Calculated Molecular Weight | 48.9 kDa |
| Observed Molecular Weight | 60 kDa |
| Tag | C-Fc |
| Bio-activity | Not validated for activity |
| Purity | > 90% as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU/mg of the protein as determined by the LAL method |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis. |
| Background | The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with an the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with an interleukin 2 receptor alpha deficiency. |
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