Recombinant Human IL17RA Protein(His Tag) (PDMH100167)
For research use only.
| Synonyms | IMD, MGC, CTLA, CANDF, CDw, IL17RA, CANDF5, CD217, CDw217, IL-17RA, IL17R, IMD51, hIL-17R, CD127, CD217 antigen, CDW127, CTLA8, HIL 17R, hIL17R, I17RA, IL 17 receptor, IL 17 receptor A, IL 17RA, IL17, IL-17 R alpha, IL-17 receptor A, IL17A receptor, IL-17R, IL17R-A, IL17-RA, IL-17R-alpha, IL7RA, ILRA, Interleukin 17 receptor A, Interleukin-17 receptor A, MGC10262, CDw217, Interleukin-17 receptor A |
| Species | Human |
| Expression Host | Mammalian |
| Sequence | Leu33-Trp320 |
| Accession | Q96F46 |
| Calculated Molecular Weight | 31.6 kDa |
| Observed Molecular Weight | 50-65 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
| Purity | > 95% as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU/mg of the protein as determined by the LAL method |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis |
| Background | Interleukin-17 receptor (IL-17R), also known as Interleukin-17 receptor A (IL-17RA) and CD217 antigen (CD217), is a cytokine receptor that binds interleukin 17. IL-17R/IL-17RA (CD217) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17R/IL-17RA (CD217) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor IL-17RA play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Defects in IL-17R/IL-17RA (CD217) are the cause of familial candidiasis type 5 (CANDF5). CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails, and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. |
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