Recombinant Human IL-29 protein(His Tag) (PKSH034114)
For research use only.
| Synonyms | IFN-lambda, Interleukin, ytokine Zcyto, Cytokine Zcyto, IFNL, ZCYTO, IFN-λ, lambda, Cytokine Zcyto21, IFN-lambda-1, IFN-λ1, IL-29, interferon, interferon lambda 1, Interferon lambda-1, Interleukin-29, lambda 1, ytokine Zcyto21, IL29, ZCYTO21, IFNL1 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Pro 23-Thr 200 |
| Accession | Q8IU54 |
| Calculated Molecular Weight | 20.7 kDa |
| Observed Molecular Weight | 22 kDa |
| Tag | C-His |
| Bio-activity | Measure by its ability to induce IL-8 secretion in HuH7 cells. The ED50 for this effect is <6 ng/mL. |
| Purity | > 98 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 0.1 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation |
Lyophilized from sterile PBS,pH 8.0. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
| Background | Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression. |
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