Recombinant Human IL-29 Protein (PDMH100371)
For research use only.
| Synonyms | IFN-lambda, Interleukin, ytokine Zcyto, Cytokine Zcyto, IFNL, ZCYTO, IFN-λ, lambda, Cytokine Zcyto21, IFN-lambda-1, IFN-λ1, IL-29, interferon, interferon lambda 1, Interferon lambda-1, Interleukin-29, lambda 1, ytokine Zcyto21, IL29, ZCYTO21, IFNL1 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Met1-Thr200 |
| Accession | Q8IU54 |
| Calculated Molecular Weight | 22 kDa |
| Observed Molecular Weight | 34 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
| Purity | > 90% as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU/mg of the protein as determined by the LAL method |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis. |
| Background | Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression. |
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